Biology

A single-cell multi-omic and spatial atlas of B-cell lymphomas reveals differentiation drives intratumor heterogeneity

B-cell lymphomas maintain plasticity in cellular differentiation, generating multiple maturation states within tumors that occupy distinct spatial niches, carry different genetic …

donnacha-fitzgerald

• Sep 27, 2024 • 1 min read

Biology

A pathway coordinated by DELE1 relays mitochondrial stress to the cytosol

We identified a previously unknown signaling pathway that relays mitochondrial stress to the cytosol and activates the integrated stress response.

evelyn-fessler

• Mar 4, 2020 • 1 min read

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Biology

A single-cell multi-omic and spatial atlas of B-cell lymphomas reveals differentiation drives intratumor heterogeneity

A pathway coordinated by DELE1 relays mitochondrial stress to the cytosol