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The Challenge of Cell Segmentation in Spatially Resolved Transcriptomics featured image
Spatial Omics

The Challenge of Cell Segmentation in Spatially Resolved Transcriptomics

Cell segmentation is an underappreciated but major source of error in spatially resolved transcriptomics. This perspective argues for shared metrics, benchmarks, and reporting …

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A single-cell multi-omic and spatial atlas of B-cell lymphomas reveals differentiation drives intratumor heterogeneity featured image
Biology

A single-cell multi-omic and spatial atlas of B-cell lymphomas reveals differentiation drives intratumor heterogeneity

B-cell lymphomas maintain plasticity in cellular differentiation, generating multiple maturation states within tumors that occupy distinct spatial niches, carry different genetic …

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